{"product_id":"natriumdichloracetat-dca","title":"Sodium dichloroacetate (DCA)","description":"\u003ch2 class=\"PDq2pG_selectionAnchorContainer\"\u003eSodium Dichloroacetate (DCA) – High-Purity Substance, at least 99% (50 g)\u003cspan class=\"PDq2pG_selectionAnchor\"\u003e\u003c\/span\u003e\n\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSodium dichloroacetate\u003c\/strong\u003e, abbreviated as \u003cstrong\u003eDCA\u003c\/strong\u003e, is the sodium salt of dichloroacetic acid. The compound has been the subject of biochemical and medical research for decades, particularly in connection with the energy metabolism of cells and the function of mitochondria.\u003c\/p\u003e\n\u003cp\u003eThe product contains \u003cstrong\u003e50 g of high-purity sodium dichloroacetate without added fillers\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e at least 99% according to product specification\u003cbr\u003e\u003cstrong\u003eContent:\u003c\/strong\u003e 50 g\u003cbr\u003e\u003cstrong\u003eCAS number:\u003c\/strong\u003e 2156-56-1\u003cbr\u003e\u003cstrong\u003eEmpirical formula:\u003c\/strong\u003e C₂HCl₂NaO₂\u003cbr\u003e\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e 150.92 g\/mol\u003c\/p\u003e\n\u003ch3\u003eComposition and Quality\u003c\/h3\u003e\n\u003cul\u003e\n\n\u003cli\u003eSodium dichloroacetate, at least 99%\u003c\/li\u003e\n\n\u003cli\u003eNo added fillers\u003c\/li\u003e\n\n\u003cli\u003eNo colorants or flavorings\u003c\/li\u003e\n\n\u003cli\u003eHigh-purity powdered substance\u003c\/li\u003e\n\n\u003cli\u003ePackaged in a tightly sealed container\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003cp\u003eSince sodium dichloroacetate is hygroscopic, the packaging should be immediately resealed after each removal.\u003c\/p\u003e\n\u003ch3\u003eScientific Background\u003c\/h3\u003e\n\u003cp\u003eThe focus of DCA research is \u003cstrong\u003ecellular energy metabolism\u003c\/strong\u003e. Sodium dichloroacetate is known as an inhibitor of \u003cstrong\u003epyruvate dehydrogenase kinase\u003c\/strong\u003e, or PDK for short.\u003c\/p\u003e\n\u003cp\u003eBy inhibiting this enzyme, the pyruvate dehydrogenase complex can be influenced. This mechanism is important for the scientific investigation of the transition between glycolysis and mitochondrial energy production.\u003c\/p\u003e\n\u003ch4\u003eMitochondria and Cell Metabolism\u003c\/h4\u003e\n\u003cp\u003eMitochondria play a central role in the energy production of cells. DCA is investigated in laboratory and clinical research contexts with regard to the following processes, among others:\u003c\/p\u003e\n\u003cul\u003e\n\n\u003cli\u003ePyruvate and glucose metabolism\u003c\/li\u003e\n\n\u003cli\u003emitochondrial energy production\u003c\/li\u003e\n\n\u003cli\u003eformation and breakdown of lactate\u003c\/li\u003e\n\n\u003cli\u003eregulation of pyruvate dehydrogenase\u003c\/li\u003e\n\n\u003cli\u003ecellular signaling pathways\u003c\/li\u003e\n\n\u003cli\u003eprogrammed cell death, also known as apoptosis\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003ch4\u003eWarburg Effect\u003c\/h4\u003e\n\u003cp\u003eAnother research focus is the so-called \u003cstrong\u003eWarburg effect\u003c\/strong\u003e. This describes an altered energy metabolism of certain cells, in which glycolysis is increasingly used despite the presence of oxygen.\u003c\/p\u003e\n\u003cp\u003eIn \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2567082\/\" target=\"_blank\" title=\"Studien die Reaktivierung\" rel=\"noopener\"\u003eexperimental research models, it is investigated\u003c\/a\u003e whether influencing PDK activity can change mitochondrial metabolism and apoptotic signaling pathways. However, these laboratory findings do not mean that DCA is an approved treatment for cancer. PubChem describes DCA as a PDK inhibitor with potential antineoplastic activity, but this refers to a research subject and not an approved cancer therapy. \u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch Context and Areas Investigated\u003c\/h3\u003e\n\u003cp\u003eSodium dichloroacetate has been investigated in various scientific contexts since the 1970s. These include:\u003c\/p\u003e\n\u003cul\u003e\n\n\u003cli\u003eDisorders of pyruvate and lactate metabolism\u003c\/li\u003e\n\n\u003cli\u003emitochondrial dysfunction\u003c\/li\u003e\n\n\u003cli\u003elactic acidosis\u003c\/li\u003e\n\n\u003cli\u003ecellular oxygen and energy metabolism\u003c\/li\u003e\n\n\u003cli\u003eneurological and metabolic research models\u003c\/li\u003e\n\n\u003cli\u003eexperimental research on atypical cell changes\u003c\/li\u003e\n\n\u003cli\u003epharmacological investigation of PDK inhibition\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003cp\u003eDCA is also being investigated in \u003ca href=\"http:\/\/medicorcancer.com\/dca-therapy-data\/\" target=\"_blank\" title=\"Praxis und in Studien\" rel=\"noopener\"\u003eexperimental oncological studies\u003c\/a\u003e. However, the existing \u003ca href=\"https:\/\/www.cancer.org\/\" target=\"_blank\" title=\"Studien der Pharmaindustrie\" rel=\"noopener\"\u003eresearch results do not justify\u003c\/a\u003e general effectiveness or independent use in glioblastomas, carcinomas, lymphomas, or other tumor diseases.\u003c\/p\u003e\n\u003ch3\u003eUsage\u003c\/h3\u003e\n\u003cp\u003eThis product is offered as a high-purity chemical substance.\u003c\/p\u003e\n\u003cp\u003eHandling must only be carried out in accordance with the product specification, the safety data sheet, and the intended professional use.\u003c\/p\u003e\n\u003cp\u003eDo not use internally without professional supervision. No medical dosage is deliberately given on this product page.\u003c\/p\u003e\n\u003ch3\u003eNotes and Restrictions\u003c\/h3\u003e\n\u003cp\u003eThis product is not an approved medicinal product for the treatment of cancer or other diseases.\u003c\/p\u003e\n\u003cp\u003eNot intended for self-medication.\u003c\/p\u003e\n\u003cp\u003eAvoid contact with eyes, skin, and respiratory tract. Sodium dichloroacetate can irritate skin, eyes, and respiratory tract. Observe appropriate protective measures when handling. \u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eDo not use during pregnancy or breastfeeding.\u003c\/p\u003e\n\u003cp\u003eKeep away from children and pets.\u003c\/p\u003e\n\u003cp\u003ePersons with neurological complaints, liver or kidney diseases should not consider independent contact with medical application.\u003c\/p\u003e\n\u003cp\u003eFor experimental, diagnostic, or therapeutic applications, a professional evaluation and compliance with the applicable regulations are required.\u003c\/p\u003e\n\u003cp\u003eStore dry, cool, and tightly sealed. Protect from moisture and direct light.\u003c\/p\u003e","brand":"Alpen Natur","offers":[{"title":"Default Title","offer_id":63248776331613,"sku":null,"price":369.0,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1037\/0488\/7645\/files\/Natriumdichloracetat-DCA.jpg?v=1782145514","url":"https:\/\/alpen-natur.ch\/en\/products\/natriumdichloracetat-dca","provider":"Alpen Natur","version":"1.0","type":"link"}